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KMID : 0614019890050010047
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Journal of Pharmaceutical Sciences (C.N.U.)
1989 Volume.5 No. 1 p.47 ~ p.52
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Selective Inhibitory Effect of New Phosphodiesterase Inhibitors on PDE Isozymes In Guinea pig Cardiac Muscle
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Lee Sun-Kyeong
Kwon Kwang-Il
Zee Ok-Pyo
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Abstract
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Selective inhibition of seven new PDE inhibitors on cyclic nucleotide PDE isozymes was investigated. Three PDE isozymes (PDE Ⅰ, Ⅱ and Ⅲ) of guinea pig left ventricular muscles were used. All tested agents inhibited cyclic AMP hydrolysis by PDE Ⅲ in a concentration-dependent manner. Some agents represented more potent and selective inhibitory effect on PDE Ⅲ than that of imazodan.
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KEYWORD
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Inotropic agents, congestive heart failure, selective PDE inhibitor
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